Clinical Presentation and Prolactin Level of ANDI (Aberration of Normal Development and Involution) Patients of Breast

ANDI (Aberration of normal development and involution) classification covers most of the benign breast conditions as a result of hormonal influence. Prolactin plays an important role in normal proliferation and differentiation of breast epithelium. The objective of this hospital based study was to find out clinical presentation and prolactin level of ANDI patients. Total 330 patients with different conditions of ANDI visited surgical out patient department of Liaquat University of Medical and Health Sciences from May 2005-May 2006. 200 were selected for their Prolactin levels measurments apart from other clinical, radiological, cytological or histopathological investigations. Only 30 (15%) patients found to have raised Prolactin. 27% of multiple fibroadenoma, 12.5% with recurrent fibroadenoma, 13.3% with cyclical nodularity, 6.5% with mastalgia, 4.8% with fibrocystic disease, 23% with fibroadenosis and 71% with galactorrehea along with fibrocystic disease were having raised Prolactin. The result of our study suggest that Prolactin hypersecretion is likely etiological factor in some of the conditions of ANDI, rest may be due to end organ hypersensitivity to normal circulating Prolactin or other hormones. Pharmacological manipulation of raised prolactin in patients can provide relief from symptoms.